Desethyl Azilsartan Medoxomil
Product Description
| Catalogue Number | D289258 |
| Chemical Name | Desethyl Azilsartan Medoxomil |
| Synonyms | 3-[[2′-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1′-biphenyl]-4-yl]methyl]-2,3-dihydro-2-oxo-1H-benzimidazole-4-carboxylic Acid (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl Ester |
| CAS Number | 1417576-00-1 |
| Molecular Formula | C₂₈H₂₀N₄O₈ |
| Appearance | White to Off-White Solid |
| Melting Point | 144 – 154°C |
| Molecular Weight | 540.48 |
| Storage | -20°C, Inert atmosphere |
| Solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| Category | Standards; Pharmaceutical/API Drug Impurities/Metabolites; |
| Applications | Desethyl Azilsartan Medoxomil is an impurity from the synthesis of Azilsartan Medoxomil (A926910). Azilsartan medoxomil is a long-acting angiotensin II receptor blocker (ARB) that is used to lower hypertension. When Azilsartan medoxomil enters the gastrointestinal tract, it is rapidly converted to its active form, Azilsartan (A926900). |
| References | Radl, S., et al.: Org. Process. Res. Dev., 17), 77-86 (2013); Baker, W. & White, W.: Pharmacotherapy, 45, 1506 (2011); Cushman, W., et al.: Hypertension, 60, 310 (2012); Lastra, G., et al.: Cardio. Med. 3, 154 (2013); Miura, S., et al.: Hypertens. Res., 36, 134 (2012); Rakugi, H., et al.: Hypertens. Res., 35, 552 (2012) |
