Ruxolitinib
Product Description
| Catalogue Number | R702000 |
| Chemical Name | (R)-Ruxolitinib (>90%) |
| Synonyms | (βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile; INCB 018424; |
| CAS Number | 941678-49-5 |
| Molecular Formula | C₁₇H₁₈N₆ |
| Appearance | White to Beige Solid |
| Melting Point | 84-89°C |
| Molecular Weight | 306.36 |
| Storage | -20°C |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Category | Standards; Chiral Molecules; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
| Applications | Ruxolitinib is a selective Janus tyrosine kinase (JAK1 and JAK2) inhibitor used in the treatment of myeloproliferative neoplasms and psoriasis. Potent JAK2 inhibitor. |
| References | Shilling, A. D., et al.: Drug Metab. Disp., 38, 2023 (2010); Mesa, R. A.: IDrugs, 13, 394 (2010); Campas-Moya, C.: Drugs Fut., 35, 457 (2010) |
